Sore and stiff knees

I have gotten the Synvisc (stuff from a rooster's cone) shots under my knee caps for 4 years now.  They lubricate the arthritis and ease the pain.  They have worked well for several years, but now seem to have no effect.  My knees are sore and stiff, even after only running a 10K yesterday.  I need to back to the doctor and see what the alternatives are that do not include breaking my running streak.  This afternoon, I ran 2 miles on the streets around the campus and took Ibuprofen tablets with my dinner.